Implantable nitinol devices typically undergo a single a high-strain event as they are loaded into a catheter, after which they are deployed into a mechanical environment that typically applies both a relatively constant mean strain and relatively low-cyclic strain amplitudes. The regions of highest strain amplitude in a device therefore typically undergo small cyclic strains off the lower plateau of the nitinol stress-strain curve. To better understand the effect of cyclic loading and strain rate on predictions of in vivo stress/strain levels in nitinol devices, the results of multiple finite element analyses using constitutive properties obtained from nitinol wire specimens subjected to multiple loading cycles over a range of strain rates were compared. Our results indicate that significant variation in predicted in vivo stresses and strains can occur over the range of cyclic loading and strain rates tested.