Laser Additive Manufacturing (LAM) has the potential to reduce the cost and lead time needed to produce of Ti-6Al-4V components for aircraft structural components. Because Ti-6Al-4V is generally used for primary structural components, any new process used to make components must be well understood prior to introduction. One aspect of this is developing an understanding of the effects of powder type, deposition process parameters, thermal treatments, and repairs on the microstructure and mechanical properties. The effects of powder type, deposition, repair, thermal processing, and other factors on the soundness, microstructure, and mechanical properties of LAM Ti-6Al-4V investigated under the Metals Affordability Initiative Program are presented.