Alloy Ti-5Al-5Mo-5V-3Cr-0.5Fe (Ti-5553) is an emerging high-strength titanium alloy with improved static mechanical properties compared with the industry workhorse Ti-6Al-4V.  Studies to date have shown that this material also has comparable or better fatigue properties to steel and Ti-6Al-4V, respectively, thus could be a replacement candidate for these alloys to achieve weight savings and/or enhanced durability.  This potential weight saving can be especially advantageous for rotorcraft where forged steel components can be replaced by a titanium alloy.  This presentation reviews work conducted on characterizing the microstructure-properties of Ti-5553 in the cast form.  Mechanical properties covered here include tensile, toughness, and fatigue behavior for microstructures achieved under different thermo-mechanical processing conditions.  The results show outstanding strength and fatigue properties relative to both wrought and cast Ti-6Al-4V.  These results will be discussed in light of potential applicability to naval airframe structures that have requirements for such alloys for current and next generation aircraft systems.  This work was supported by the Naval Air Warfare Center.