Alloy Ti-5Al-5Mo-5V-3Cr-0.5Fe (Ti-5553) is an emerging high-strength titanium alloy with improved static mechanical properties compared with the industry workhorse alloy Ti-6Al-4V.  Previous studies have shown that this material also has comparable or better fatigue properties to 4340 steel and Ti-6Al-4V, respectively, thus could be a replacement candidate for these alloys to achieve weight savings and/or enhanced durability.  The ability to cast complex net shapes from a high strength titanium as this also offers the potential to save both cost and weight over traditionally forged aerospace components.  This presentation highlights the latest results obtained in a Navy program to understand the effect of processing on the microstructure-properties of cast Ti-5553.  Mechanical properties covered here include tensile, toughness, and fatigue behavior for microstructures achieved under different thermo-mechanical processing conditions.  The results achieved to date show outstanding strength and fatigue properties relative to both wrought and cast Ti-6Al-4V.  These properties will be discussed in light of potential applicability to airframe structures that have requirements for such alloys for current and next generation commercial and military systems.  This work was supported by the Naval Air Warfare Center.