The end use requirements for Drawn Filled Tube, DFT®, wire for bio-conductor leads present difficult challenges to achieve the desired performance of these permanent implant devices. This composite wire uses an outer layer of ASTM F562 (cobalt-nickel-chromium-molybdenum alloy) material for strength and corrosion resistance combined with a core material of silver to provide high conductivity properties. The purpose of this paper is to review the property improvements of this alloyed wire through the use of enhanced melting chemistry. The new chemistry is the 35N LT® material which meets the requirements of ASTM F 562. It will be shown that the reduction in Titanium content of the melt will provide reduced inclusion sizes and distribution, improved surface finish and greatly improved fatigue life of wire forms under various conditions pertinent for the medical-device industry.