Many modern medical implants such as stents and filters are made from Nitinol tubing that contains textures due to tubing drawing processes. Although it is well known that textures induce anisotropy in Nitinol, their impact on the fatigue performances has not been studied. The present study is to address this issue from tensile fatigue tests. The specimens are made from Nitinol tubing from both axial and circumferential directions to achieve this goal. The tests are done under displacement-controlled conditions and nonlinear finite element analyses are performed so that the same mean and alternating strains are applied on specimens of both directions. Results are presented as strain-life format for mean strains from 1.5% to 8% in the low-cycle fatigue regime. Differences in fatigue resistance are discussed in conjunction with the stress-strain response on the first loading and unloading of the specimens.