Nanoplatforms for Nanomedicine

Biocompatible nanomaterials are key components of novel approaches to addressing the major problems of modern medicine. A variety of nanoplatforms have emerged that have resulted in dramatic developments in imaging, early diagnosis and targeted delivery of therapeutics. Several varieties of nanoplatforms: metal, semiconducting polymeric and magnetic nanoparticles, liposomes, micelles, and nanoassemblies, have been developed that can enable efficacious delivery of drugs, DNA or energy to localized sites such as tumors, using targeting agents such as antibodies or guided navigation using magnetic fields. The optical properties of these nanoparticles offer an attractive alternative to the fluorophore-based staining and labeling of biological samples, and have potential use in a wide range of biological and physical applications. Magnetic nanoplatforms for theranostics combine multiple functionalities including imaging, magnetic guidance to the disease site, delivery of the drug payload through sustained as well as triggered drug release. Nanoporous coatings have been developed for implants, cardiovascular stents and fiducials used in image guided radio therapy. The non-erodable coatings show sustained release profiles that are comparable to those from erodible polymer platforms, but without the problems of delamination. A new doctoral program has also been established incorporating new courses and interdisciplinary research in nanomedicine.

Supported by National Cancer Institute and the National Science Foundation