Leukocyte adhesion to endothelial cells and their migration into tissue is an expected response to inflammation.  Understanding the body’s inflammation response to foreign materials will aid in the improvement of existing biomaterials or development of new biomaterials which can lead to cost-effective and improved quality implantable products.  For this study, we utilized surface treated binary and ternary titanium alloys.  Cell growth was quantified using electrochemical impedance spectroscopy (EIS) during static immersion as the change in electron-transfer resistance resulted from the adhesion of cells on the alloy surface.  Leukocytes were induced on the existing cell layer and leukocyte adhesion was monitored indirectly as a result of the change in endothelial cell-alloy adhesion.   It is expected that the adhesion of leukocytes will reduce the adhesion of endothelial cells to the alloys and such a reduction may facilitate the migration of leukocytes into tissues.