Titanium–tantalum alloys offer a range of desirable properties that make them of interest for implantable medical devices.  An advanced PM process has been developed to produce these alloys that are extremely difficult to prepare by conventional melt processes.  The properties and wire drawing characteristics of these PM Ti-Ta alloys are being investigated in the range of 30% to 95% Ta.  Several compositions have been found to be of interest for medical devices.  Specific Ti-base alloys possess a unique combination of low modulus and high yield strength that makes them promising for guidewires and for mitigating “stress-shielding” of bone in orthopedic implants.  At higher Ta compositions Ti–Ta alloys undergo the martensitic transformations that are indicative of potential superelastic or shape-memory behavior required for self expanding vascular stents.  High Ta compositions have the unique combination of high modulus and relatively low yield strength, making these alloys attractive for low recoil, mechanically deployed stents.  The results of this ongoing investigation will be discussed.