Multilayer buildup on directionally solidified GTD-111 superalloy was studied by direct laser deposition using the laser engineered net shaping (LENS) system. Rene-80 powder was used as the filler material to deposit on the GTD-111 base metal. Process parameters, including the laser power, travel speed and powder feeding rate, were systematically varied to study their effect on the resulting microstructure of the cladding. The cross sectional shape and area, the solidification structure, and the primary dendrite spacing of the cladding were correlated with the processing parameters. Directional solidification was shown to be achievable in the cladding with optimal combinations of process parameters. However, "stray" crystals were observed in the mostly directional solidified structures. The second-phase particles in the base metal seemed to serve as the nucleation sites for the formation of "stray" crystals.