The prime reason for life casualties in fire is not the fire itself but suffocation caused by presence of carbon monoxide. It is reported by American Medical Association that CO is responsible for about 1000 deaths per year and about 10000 physical injuries. Carbon monoxide can be lethal at a concentration of more than 400 ppm. Depending upon cases, fire can contain as high as 3600 ppm of carbon monoxide. The goal of the work undertaken here is to develop a gas mask capable of removing carbon monoxide from 3600 ppm to less than 400 ppm for at least 15 – 60 minutes while meeting other CBRN (chemical, biological, radiological and nuclear) standards proposed by NIOSH. The present work deals with developing a suitable microfibrous entrapped catalyst for CO removal. Microfibrous materials are new types of materials suitable for applications where high surface area is needed. These materials also have other advantages such as higher contacting efficiency, improved thermal management and very low pressure drop. The paper would discuss state-of-the-art microfibrous entrapped materials, catalyst development, catalyst testing and gas mask development aspects.