A multidiciplinary design project integrating materials science, applied mechanics and quantum physics explores the concurrent design of materials and structures for anti-terrorism blast protection applications. Dynamic simulations of the blast response of novel truss-core sandwich structures define material property requirements, while multiscale modeling is integrated in the computational design of new steels optimized specifically for efficient blast protection. While ONR-sponsored graduate research addresses naval hull applications, advanced undergraduate multidisciplinary design class projects address adaptation of the technology to civilian anti-terrorism applications, with emphasis on ground transportation systems.