Deciding to clean with aqueous cleaners to replace hazardous solvents is easy. Selecting the right aqueous cleaner can be hard. The goal of this presentation is to help make that selection process easier. The relationship between cleaning method, the type of soil, the type of substrate, the type of rinsing, the type of drying, handling and waste treatment considerations will be reviewed with guidelines given for selecting the right kind of aqueous cleaner. These types of aqueous cleaners will be defined within the framework of these detergent selection guidelines. Key concepts from the chapters on “Testing and Selecting a Detergent and Cleaning System” and “The Chemistry of Aqueous Cleaning” from The Aqueous Cleaning Handbook will be presented.