Porous calcium phosphate ceramics and glass ceramics have received much attention as bone implant materials because of their superior mechanical, structural and bioactive properties. Selection of materials for important biomedical applications is a complicated process which involves compromises between biocompatibility and mechanical performance. This is particularly true for the design of load-bearing implants and tissue scaffolds. In the application as the load-bearing tissue replacement scaffold, an accurate determination of the scaffold mechanical properties is very important in understanding the mechanical interaction between the implant and surrounding tissues, and in developing new materials that biomechanically match the replaced bone tissues. Porosity of a tissue-engineered scaffold plays a significant role as an important biological factor for bone growth on the scaffold structural properties. The objective of this paper is to present our recent study on using the Continuous Depth-Sensing Indentation approach to characterize the mechanical properties of various porous hydroxyapatite (HA, Ca10(PO4)6(OH)2) and b-tricalcium phosphates (b-TCP, Ca3(PO4)2) bone replacements fabricated through the TheriFormTM three-dimensional printing process. The presentation will cover: 1) the TheriFormTM process for fabrication of tissue replacements; 2) data analyses in Continuous Depth-Sensing Indentation; and 3) testing results. A Finite Element Analysis (FEA) will be conducted to simulate the indentation process and results will be compared with the experimental data.