Surface Engineering Home      Exposition      To Register      ASM Homepage
Back to "Session 1: Processing of Prosthetic Devices" Search
  Back to "Biomedical and Dental Applications" Search  Back to Main Search

Wednesday, May 17, 2006 - 11:30 AM
BDA1.4

Biocompatible Coatings and Their Response to Endothelial Cell Seeding

N. Ali, Y. Kousar, J. Gracio, University of Aveiro, Aveiro, Portugal; T. Okpalugo, W. Ahmed, University of Ulster, Newtownabbey, United Kingdom; V. Singh, Louisiana State University, Baton Rouge, LA; A. A. Ogwu, University of Paisley, Scotland, United Kingdom; E. I. Meletis, The University of Texas at Arlington, Arlington, TX

Biocompatible coatings and their response to endothelial cell seeding
 N. Ali1, Y. Kousar1, T. I. Okpalugo2, V. Singh3, M. Pease3, A. A. Ogwu4, J. Gracio1, E. Titus1, E. I. Meletis5, W. Ahmed2* and M. J. Jackson6.
 1          Centre for Mechanical Technology and Automation, University of Aveiro,          Portugal.
2          Northern Ireland Bio-Engineering Centre, NIBEC, University of Ulster, UK.

3          Center for Advanced Microstructures and Devices, Louisiana State University, Baton Rouge, LA-70806, U.S.A.4          Thin Film Centre, University of Paisley, Scotland, UK
5          Materials Science and Engineering, The University of Texas at Arlington, TX, U.S.A.
6          College of Technology, Purdue University, IN 47907-2021, USA
*          E-mail: w.ahmed@ulster.ac.uk
Abstract
In this investigation, chromium modified diamond-like-carbon (Cr-DLC), silicon-DLC (Si-DLC), polycrystalline diamond, titanium oxide, cobalt chrome and TiAlV alloyed biomaterials were studied for potential applications in mechanical heart valves. The biocompatible coatings (Cr-DLC, Si-DLC, polycrystalline diamond, titanium oxide) were deposited using magnetron sputtering, chemical vapour deposition (CVD), hot-filament CVD and sol-gel techniques. The biological response of human micro-vascular endothelial cells (HMV-EC) seeded onto the above biomaterial/coating surfaces was evaluated in terms of initial cell attachment and growth. All the coatings were characterized for physical properties using a range of techniques, including Raman spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), secondary ion mass spectroscopy (SIMS), contact angle technique and XPS. Our results show that titanium oxide coatings displayed superior results to other coatings used in this study.