Nitinol alloys are rapidly becoming the materials of choice for self-expanding stents, graft support systems, filters, baskets, and various other devices for minimally invasive interventional and endoscopic procedures due to their excellent superelasticity, radiopacity and shape memory properties. Although, several studies have shown that Nitinol possesses good biocompatibility, its high nickel content and possible dissolution still remain a concern. High concentrations of nickel are toxic and carcinogenic and may cause cellular damage and harmful effects on bones. Electrochemical polarization was utilized to compare the biocompatibility of nitinol alloy and 316L stainless steel in vitro with Hanks and Ringer solution. The rate of corrosion of nitinol determined at 37 °C and 39.5 °C was comparable to that of 316 stainless steel.