Porous Nitinol (PNT) is renowned for its usage as a medical implant material and is employed in applications, such as bone graft substitutes, intervertebral and lumbar inter body fusion devices, maxillo-facial and cranial repairs, etc. However, possible Ni release from PNT still remains a concern due to its large surface area and complex morphology. In this investigation, cyclic potentiodynamic polarization tests as per ASTM F 2129-08 were conducted on PNT in phosphate buffer saline (PBS) solution at 37 °C to determine the corrosion resistance and the concentration of metal ions released. The amount of Ni released during the corrosion tests was added exogenously to the cell culture media, which was used to determine its cytotoxic effect on osteoblast cells by SRB assays. The morphology of the PNT before and after corrosion was examined by SEM. Osteointegration of human osteoblast cells on PNT surface was also assessed.