Currently used alloys for hip replacement such as CP Ti, Co-Cr, Ti-6Al-4V either have limitations of poor osteoblast integration, metal-on-metal lubrication, radiopacity or loosening of joints. Ti-Ta alloys have recently received much interest due to their corrosion resistance, biocompatibility, corrosion fatigue characteristics, shape memory behavior, radiopacity and metallurgical properties.  As such, it is considered a prime candidate for applications such as metal-on-metal spinal disc replacements, orthopedic implants, nickel-free cardiovascular stents, dental posts and wires.  The corrosion resistance of Ti-Ta alloys was studied using ASTM F 2129-08 cyclic polarization in-vitro corrosion tests in phosphate buffered saline (PBS) at 37 °C. A comparative analysis was conducted on endothelial and osteoblast cell proliferation using fluorescence microscopy. Additionally, the microstructure was examined using X-ray diffraction (XRD) and transmission electron microscopy (TEM). The morphology was studied using scanning electron microscopy (SEM) and phase transformation characteristics were analyzed using differential scanning calorimetry (DSC).