Identifying non-hazardous solvent cleaning substitutes is a challenging task with thousands of possible alternatives. Ideally, the replacement formulations should strive to be safer, less toxic and as effective as the current solvents. In an effort to develop and promote environmentally-friendlier, safer cleaning alternatives three types of Bio-Based solvents were evaluated for their effectiveness in removing metal working and non-metal working fluids under laboratory controlled conditions. The bio-based solvents evaluated at SSL were shown to have many possible uses in surface cleaning applications. Attention to cleaning methodology, including rinsing and drying, will allow for optimum effectiveness to be achieved.