Handheld molecular diagnostics will become the dominant diagnostic tool for all of medicine once rapid and less expensive detection methods are developed. However, the existing arrays are passive: the motion of DNA in the sample is only governed by diffusion, which make the DNA transport slow and limits the hybridization rate. Electrokinetics is a widely investigated solution to this problem: electrical fields are applied in microarrays, which can induce particles and fluid motion. In addition, traditional molecular diagnostic detection has relied on fluorescent or radioactive labels, and signal transduction is performed with equipment that greatly increases size and cost of the whole system. Electronic detection is expected to involve less complicated and smaller instrumentation while detection limits are maintained. This tutorial will review current efforts developed in the field toward the goal and present new progress performed at Microfluidics and Biosensors Laboratory, Worcester Polytechnic Institute.