Laser etching is a common method for marking surgical instruments and the resulting laser mark is a common site for corrosion to occur. To understand the effect of the laser marking parameters upon the corrosion resistance of the laser mark, coupons made from different instrument materials were laser marked using several different combinations of speeds, wattages, and frequencies. Corrosion evaluation of the coupons was conducted by submerging the samples in Ringers solution until corrosion appeared. Samples were graded on readability and the amount of corrosion. Several trials were conducted and the experiment was also repeated using only the best performing parameters to avoid possible anodic effects of the poor performers. Finally, photographs were taken of some of the representative samples to help understand the processing parameter’s effects on the laser disturbed surface.