Metal and ceramic injection molding can produce near-net shape components from generally accepted biocompatible materials, such as 316L stainless steel, Co-28Cr-6Mo, commercially pure titanium, and alumina. The key processing issues associated with the fabrication of these materials is reviewed. Important factors include particle size and shape, impurity content, sintering atmosphere, sintering temperature, heat treatment, and hot isostatic press cycles. These processing parameters are correlated to the final microstructure and the mechanical properties. Results from the injection molded materials are compared with the corresponding ASTM specifications.