Thursday, 21 August 2003
This presentation is part of : Thursday Poster Sessions

PD-077 A Brain Evoked Potential Examination in Alzheimer's Disease, Mild Cognitive Impairment, and Normal Control

Shifu Xiao and Xingshi Chen. Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai, China

Objective: To examine brain evoked potentials in patients with Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI).

Methods: 24 patients with AD, 23 patients with MCI and 29 normal controls (NC) were recruited. The auditory brainstem evoked response (ABR), contingent negative variation (CNV), P300 and visual evoked potential (VEP) were assessed respectively.

Results: Most criteria of the BEPs assessed in AD patients showed significantly different from either MCI group or NC group. Compared with the NC group, the elderly with MCI demonstrated significantly decreased amplitudes of ABR wave V and P3 of P300 (P<0.01). A linear discriminant function was obtained with stepwise discriminant analysis and variables of absolute amplitudes and latent periods of ABR wave III and wave V, reactive time of CNV and amplitude of P300 provided a discriminative accuracy of 84.2%.

Conclusion: Multiple brain evoked potentials assessment is helpful in diagnosis and understanding the brain bio-electric changes of the patients with AD or MCI, and findings suggest that decreased absolute amplitudes of wave V and P3 are valuable in early diagnosis of AD.

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