Objective: To study the feature of regional cerebral metabolism rate of glucose in patients with mild cognitive impairment (MCI) by positron emission tomography (PET) and its relationship with neuropsychological test.
Method: PET, MMSE, WMS, and GDS were conducted in 10 patients with MCI and 11 health volunteers as a control group (HC).
Results: Scores of MMSE and WMS achieved by MCI patients were lower than those by HC (p<0.01). The rCMRglc of orbital gyrus and putamen were lower in MCI group than that in HC group (p<0.05). The rCMRglc of many parts of the brain, such as orbital gyrus, putamen, middle and inferior temporal gyrus, left hippocampus and parahippocampal gyrus, cinggulate gyrus, left amygdaloid body, precentral gyrus, postcentral gyrus, and medial occipitotemporal gyrus were correlated negatively with age. Also, many parts of the brain, such as left putamen, temporal lobe, anterior cingulate gyrus, left insular lobe, amygdaloid body, precentral gyrus, postcentral gyrus, and medial occipitotemporal gyrus was correlated positively with MMSE. Left putamen, temporal lobe, left insular lobe, precentral gyrus, and postcentral gyrus were correlated positively with WMS. While right putamen, right inferior temporal gyrus, precentral gyrus, and left postcentral gyrus were correlated positively with years of education. However, only left amygdaloid body was correlated with sex positively.
Conclusion: The rCMRglc is lower in orbital gyrus and putamen of MCI patients. Their rCMRglc is correlated with their cognitive impairment severity, age, years of education, and sex.
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