Objective: To present population-based, age-standardized incidence rates for Cognitive Impairment No Dementia (CIND).
Design: The Indianapolis Study of Health and Aging is a longitudinal, population-based study of African Americans, aged 65 and older.
Materials and Methods: Subjects were seen for baseline survey and 2- and 5-year follow-up. Each assessment used a 2-stage design with in-home screening followed by full diagnostic evaluation of a subsample of participants based on screening performance with sampling for false negatives. Specific criteria for CIND were used; diagnosis was by consensus panel.
Results: The inception cohort numbered 2,212 persons. A total of 1,698 participants completed the follow-up (144 were demented or CIND at baseline, 217 died before follow up, and 153 were lost to follow-up). The group completing follow-up averaged 73.3 ± 6.7 years of age and 9.9 ± 6.7 years of education. There were 26 incident cases of CIND at 2-years and 62 incident cases at 5-year follow-up. The age-standardized annual incidence rates were: 3.39% (95% confidence interval [CI] 1.05, 5.72) for age 65-74, 6.11% (95% CI 3.76, 8.45) for age 75-84, and 9.12% (95% CI 4.82, 13.42) for age 85 and older. The overall age-standardized incidence of CIND in this population was 4.77% (95% CI 3.15, 6.41).
Conclusions: Among elderly African Americans, the incidence rate of CIND increases with increasing age and is higher than published incidence rates for Alzheimer disease at least among the young-old and old-old. The increased incidence of CIND relative to Alzheimer's disease is likely due to the presence of multiple causes and variable clinical outcomes in CIND in these age bands.
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