Disturbed sleep in Alzheimer’s disease (AD) is a major clinical problem. The 44 subjects in this report were patients who were participants in an ongoing longitudinal study of AD at the Stanford/Veterans Affairs NIA Alzheimer’s Disease Core Center (ADCC). Rest/activity data were collected at 6-month intervals by means of a wrist-worn, watch-size ambulatory motion-detecting device, the Actigraph (Ambulatory Monitoring Systems, Inc., Ardsley, New York 10502). There was little decline in the mean slope for the 25 patients with APOE e4 status (-1.7% SE/stage; Student’s t = -1.12, p = .28) versus statistically significant decline in the mean slope for those 19 patients with Non-e4 status (-8.6 % SE/stage; Student’s t = -3.46, p < .005). The difference between these two slopes is statistically significant (two sample t-test, t = -2.48, df = 42, p < .05). These results suggest that APOE status affects rate of change of sleep parameters in AD patients.
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