Objectives: To investigate whether aggravation of leukoaraiosis can be controlled by means of long-term correction of the platelet hyper-aggregability.
Design: A case-control study.
Materials and Methods: 21 patients with leukoaraiosis who had been observed for 4.1 years and 21 age-matched controls were selected to examine whether aggravation of leukoaraiosis could be controlled by means of long-term correction of the platelet hyper-aggregability. Platelet aggregability was estimated by an optical analytical method using 2 different concentrations each of ADP and collagen (the double ADP method). Hyper-aggregability and non-hyper-aggregability were defined with this method.
Results: Statistically significant differences were observed between the 2 groups. In the non-corrected group, moderate to severe aggravation of leukoaraiosis was observed in a large number of patients, while in the corrected group, only a small number of patients showed aggravation of leukoaraiosis, and the aggravation was mild in most of these cases. That is, the number of patients showing aggravation of deep white-matter hyperintensity was 9 in 21 in the non-corrected group versus 4 in 21 in the corrected group, and for aggravation of periventricular hyperintensity, these numbers were 7 in 21 verse 1 in 21, respectively. Thus, the difference was more significant if the degree of aggravation was taken into account.
Conclusion: It is concluded that aggravation of leukoaraiosis is greatly inhibited by long-term correction of the platelet hyper-aggregability.
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