A new classification of neurodegenerative disorders has recently been proposed, led by work in Oxford (UK) (Spillantini et al 1998, Goedert 1999) and supported by work in the USA (Dickson et al 1999), in which neurodegenerative disorders are classified according to the predominant protein in intraneuronal inclusion bodies-synuclein (mainly alpha) or tau.
The major synucleinopathies are Parkinson's disease, dementia with Lewy bodies, and multi-system atrophy. The clinical features of these disorders (Byrne 2001) will be reviewed, with particular emphasis on disorders of sleep and the influence of age and gender on clinical profiles, including original work on gender differences from the author's own work
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