Thursday, 21 August 2003
This presentation is part of : Thursday Poster Sessions

PD-074 Behavioral and Psychological Symptoms in Alzheimer's Disease: A Study of Frequency in a Brazilian Outpatient Sample

Mariana Franciosi Tatsch1, Renata Avila2, Eduardo Vilodres Campanha3, Sonia Edda Zevallos Bustamante3, Mário Rodrigues Louzã3, and Cássio Machado de Campos Bottino1. (1) Psychiatry, University of São Paulo, São Paulo, Brazil, (2) Psychiatry Institute, Univerity of São Paulo, São Paulo, Brazil, (3) Psychiatry Institute, University of São Paulo, São Paulo, Brazil

Behavioral and psychological symptoms in dementia (BPSD) are common and very distressing for patients and caregivers. There is a wide variation in the rates of BPSD among patients in nursing homes, community and hospitals.

Objective: To investigate the frequency of BPSD in a Brazilian outpatient sample with Alzheimer's disease (AD).

Methods: We studied 17 subjects (4 males and 13 females) with AD, diagnosed according to ICD-10 and NINCDS-ADRDA criteria, selected for an open trial with rivastigmine. The symptoms were assessed using NPI. Clinical profile and demographic features were assessed using CDR, CGI and MMSE.

Results: The sample mean age was 73.65 years (range 64-81) and mean schooling was 6.25 years (range 3-15). Mean NPI score was 14.24 (SD=10.77; range 0-40). Apathy and behavioral disturbance were the most frequent symptoms, found in 12 and 10 subjects respectively (70.6% and 58.8%) followed by disinhibition, depression and agitation, each one found in 7 subjects (41.2%). Only one patient didn’t have any BPSD. Significant correlation was found between NPI scores and gender, with female patients having more symptoms than male (r=0.652; p=0.005). There was no significant correlation between MMSE scores, CDR and CGI results and gender.

Conclusion: BPSD are highly frequent among AD patients' attended in psychogeriatric services. The finding of higher NPI scores in female gender could be only a result of selection bias and should be addressed in future studies with larger AD samples of Brazilian outpatients.

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