Objective:To evaluate the relationship between presence of dementia and frontal lobe dysfunction in late age patients with PD. Design:Parkinson’s disease (PD) with impairment of cognitive functions presents as a common clinical problem. Functional changes in the frontal lobe of late stage of PD patients are specially important. Materials and Methods:Thirty four patients (17 women and 17 men) aged 70-85 with PD were evaluated using Mini Mental State Examination (MMSE), Frontal Assessment Battery (FAB), Letter Verbal Fluency Test (VF), Trail Making Test A and B (TMT A, TMT B). Results:Mean results of MMSE were 22 (4.1), FAB 12 (4.0), VF 6.3 (3.2), TMT A 112.1 (72.9), TMT B 265.2 (121.6). In our investigated group patients showed features of frontal lobe dysfunction in employed test battery. Conclusion:Our experience suggests dysfunction of subcorticofrontal projections in late stage PD. FAB, VF, TMT appear to be sensitive scales to assess frontal lobe dysfunction in PD.
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