The Memory Impairment Screen (MIS) is an efficient, validated, rapid and easily administered screen for Alzheimer’s disease (AD) which has good sensitivity, specificity and positive predictive value. Because simple 3 word free recall tests frequently used in clinical practice have low specificity, the MIS was developed to provide a more specific and sensitive memory impairment screen. The MIS integrates controlled learning and cued recall to optimize encoding specificity, maximize retrieval, and improve discrimination. Controlled Learning is used to learn four items from different categories by identifying each item when its category cue is presented. Memory is tested by free recall and cued recall after a 2 minute delay. If any items are not retrieved by free recall, the category cues for those items are provided to elicit cued recall of those items. Using the same cues for learning and cued recall induces “encoding specificity” that optimizes cued recall and increases specificity because non-demented subjects benefit more from encoding specificity.
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