Objective:As frontotemporal dementia is the second commonest form of primary dementia and it has great impact on family members as it produces profound changes in personality, behavior, and social interaction we carried out a research to study the core signs and symptoms of not demented patients but with mild behavioral impairment until they turned into dementia. Design:A prospective cohort study of not demented patients at risk of frontotemporal dementia. Materials and Methods:Sixty nine outpatients from an university neuropsychiatric clinic were studied. Neuropsychiatry examinations, behavioral and mood scales, cognitive tests and structural and metabolic neuroimages were performed in a three year follow up period. Results:44.93% of patients turned into frontotemporal dementia, 24.64% turned into dementia of the Alzheimer type and 7.25% turned into dementia of the Lewy body type while 23.19% were neuropsychiatric patients not demented. Conclusion:A number of different signs and symptoms have been deeply described and clearly associated with focal degeneration of the frontal and temporal lobes, but those symptoms have been described mostly in the moderate to severe stages and not in the very early one. As a result, the early diagnosis of frontotemporal dementia has been a matter of discussion, in view of the diversity of clinical manifestations. In this study we describe the core signs and symptoms of not demented patients with “mild behavioral impairment” that were followed up until they turned in dementia of the frontotemporal type.
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