Objective: Late onset mania is a distinct subtype associated with medical and neurological disorders. Following the cases with diagnosed to the late onset mania were assessed in terms of clinical presentations and risk factors.
Design:
Materials and Methods: The six inpatient with diagnosed late onset mania ( first manic episode onset after 60 age) has been described.
Results: 4 of 6 patients were female and the mean age was 67.6 (+4.5) . 2 of the patients had family history in bipolar disorders and 2 patients had unipolar depressive disorder family history. 3 patients had unipolar depressive disorders before. All of them were evaluated with physical examination and laboratory investigations. 1 patient had hypertension, 1 had electroencephalograpic abnormalities. 1 had Idiopathic Parkinson’s disease. 3 patients had several manic episodes after 60 age. Most prominent symptoms were voluble and talkative speech (n = 6 ) , insomnia (n=5), grandiose and persecutory delusions (n=5), elevated mood (n=5) , increased psychomotor activity and agitation (n=4) , impulsive bahaviour (n=3), 1 patient had mixed depressed and elevated mood . Judgment and insight were failed in all patients. There were no pathologic findings in physical, neurological examination and laboratory tests except patient with Parkinson’s disease. Disturbances of conciousness were not seen .
Conclusion: Late onset mania could not be indepent from family history in all cases. Clinical presentations of these cases can be similar with young bipolar patients. A thorough examination and investigation are required in late-onset cases of bipolar disorder to rule out secondary causes.
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