Tuesday, 19 August 2003: 13:45-15:15
Michigan Room (Sheraton Hotel and Towers)

S038 Clincal Advances in Mild Cognitive Impairment and Alzheimer’s Disease

Dr. Small will present recent findings using positron emission tomography (PET) measures of glucose metabolism and amyloid plaques and tangles to detect pre-symptomatic Alzheimer’s disease. He will also describe studies designed to use these measures in testing treatments to decelerate brain aging. Recent data supporting a variety of pharmacological and non-pharmacological approaches to preventing or delaying the onset of Alzheimer’s disease will also be described. Dr. Doraiswamy will review recent studies that have used surrogate brain imaging markers, such as hippocampal volume and magnetic resonance spectroscopy measures, in monitoring outcomes in Alzheimer’s disease. He will also present results from a pilot randomized trial examining the effects of donepezil on magnetic resonance spectroscopy (MRS) and magnetic resonance imaging (MRI) measures. Dr. Lavretsky will present recent findings indicating that men have more structural brain changes (e.g., atrophy, cerebrovascular disease) on MRI compared with women. These changes appear to be related to a greater vascular disease burden in men that predisposes them to the development of depression in late life. Dr. Tariot will briefly summarize the clinical trials evidence supporting the notion that some mood stabilizers may show efficacy for the treatment of agitation in dementia. He will then review recent basic and preclinical research on the mechanism of action of this class of drugs, which converge on the surprising conclusion that some of these agents may in fact have neuroprotective potential in Alzheimer's disease. The talk will conclude with a brief glimpse of how these insights are being applied to new research activities in the laboratory as well as the clinic. Dr. Feldman will review recent findings on mild cognitive impairment and early Alzheimer’s disease, focusing on differences and similarities between the two conditions.
Chair:Gary Small
 S038-001 Early Detection and Prevention of Age-Related Memory Loss
Gary Small
 S038-002 Hippocampal Volume and Magnetic Resonance Imaging Markers in Clinical Trials
P. Murali Doraiswamy
 S038-003 Gender Differences in Brain Structure of Elderly Patients with and without Depression
Helen Lavretsky
 S038-004 Mood Stabilizers to Treat Dementia: A Case Study of Reverse Translational Research
Pierre N. Tariot
 S038-005 Mild Cognitive Impairment: New Insights into Early Alzheimer’s Disease
Howard Feldman

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