Thursday, 21 August 2003: 13:45-15:15
Chicago Sheraton Ballrooms (Sheraton Hotel and Towers)

S082 Late Onset Schizophrenia: New Wine in Old Bottle

Late-onset schizophrenia has been a controversial entity. Investigators in different continents have often used different terminology and varied diagnostic criteria to study and describe this condition. This symposium brings together scientists from 4 countries. Dilip Jeste (USA) will present an ongoing investigation of 70 patients with late-onset schizophrenia compared to 243 patients with early-onset schizophrenia. A cross-sectional and longitudinal evaluation of these patients revealed several similarities, but also some interesting differences between the two groups. Anita Riecher Rössler (Switzerland) will discuss her study of symptomatology, risk factors and course of schizophrenia in late- vesus early-onset patients. She found that not only was late-onset schizophrenia more common among women, but also the course of the illness was worse in women than in men. Perminder Sachdev and colleagues (Australia) found that late-onset schizophrenia patients were more likely to develop dementia than healthy controls, and suggest that it may be a prodrome of Alzheimer's disease. Finally, Jiahui Wong and Mary Seeman (Canada) reported a trend for improvement in cognitive deficits in post-menopausal women with late-onset schizophrenia who were treated with raloxifene, a selective estrogen receptor modulator. This is consistent with the estrogen hypothesis of late-onset schizophrenia. This session will thus highlight new and exciting data that have clinial and theoretical implications for schizophrenia in general, and late-onset schizophrenia in particular.
Chair:Dilip V. Jeste
 S082-001 Cross-Sectional and Longitudinal Comparison of Late-Onset and Early-Onset Schizophrenia Patients
Dilip Jeste
 S082-002 Late vs. Early Onset Schizophrenia: A Comparison of Representative Populations Based on Symptomatology, Risk Factors and Course
Anita Riecher Rössler
 S082-003 Long-Term Outcome of Late Onset Schizophrenia: A Five-Year Follow-up Study
Perminder S Sachdev, Henry Brodaty, Annette Koschera, B. Cullen
 S082-004 The Impact of Raloxifene on Cognitive Functioning in Postmenopausal Women with Psychosis
Jiahui Wong, Mary Seeman

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